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Title: Management of bleeding following major trauma: An updated European guideline
Authors: Rossaint, R.
Bouillon, B.
Cerny, V.
Coats, Timothy J.
Duranteau, J.
Fernández-Mondéjar, E.
Hunt, B. J.
Komadina, R.
Nardi, G.
Neugebauer, E.
Ozier, Y.
Riddez, L.
Schultz, A.
Stahel, P. F.
Vincent, J-L.
Spahn, D. R.
Publisher: BioMed Central
Citation: Critical Care, 2010, 14 (2): R52
Abstract: INTRODUCTION: Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes. METHODS: The multidisciplinary Task Force for Advanced Bleeding Care in Trauma was formed in 2005 with the aim of developing a guideline for the management of bleeding following severe injury. This document presents an updated version of the guideline published by the group in 2007. Recommendations were formulated using a nominal group process, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) hierarchy of evidence and based on a systematic review of published literature. RESULTS: Key changes encompassed in this version of the guideline include new recommendations on coagulation support and monitoring and the appropriate use of local haemostatic measures, tourniquets, calcium and desmopressin in the bleeding trauma patient. The remaining recommendations have been reevaluated and graded based on literature published since the last edition of the guideline. Consideration was also given to changes in clinical practice that have taken place during this time period as a result of both new evidence and changes in the general availability of relevant agents and technologies. CONCLUSIONS: This guideline provides an evidence-based multidisciplinary approach to the management of critically injured bleeding trauma patients.
DOI Link: 10.1186/cc8943
ISSN: 1364-8535
eISSN: 1466-609X
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2010 Rossaint et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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