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Title: Low-level C-reactive protein levels exert cytoprotective actions on human podocytes.
Authors: Pawluczyk, IZ
Yang, B
Patel, SR
Saleem, MA
Topham, PS
First Published: Aug-2011
Citation: NEPHROL DIAL TRANSPLANT, 2011, 26 (8), pp. 2465-2475
Abstract: Albuminuria and elevated C-reactive protein (CRP) levels are common manifestations of many inflammatory diseases. Cardiovascular-based drugs, with secondary anti-inflammatory actions, such as angiotensin-converting enzyme-inhibitors are able to reduce both proteinuria and CRP levels, raising the question of whether CRP directly influences the processes that result in proteinuria. As proteinuria is thought to be induced as a result of podocyte dysfunction, we investigated whether there is a pathomechanistic link with CRP.
DOI Link: 10.1093/ndt/gfq830
eISSN: 1460-2385
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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