Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/25479
Title: Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.
Authors: Hollox, Edward J.
Davies, J.
Griesenbach, U.
Burgess, J.
Alton, E. W.
Armour, J. A.
First Published: 7-Dec-2005
Publisher: BioMed Central
Citation: Journal of Negative Results in BioMedicine, 2005, 4, pp. 9-9
Abstract: Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy number between 2 and 12 in different individuals. We determined the copy number of this locus in 355 patients with cystic fibrosis (CF), and tested for correlation between beta-defensin cluster genomic copy number and lung disease associated with CF. No significant association was found.
DOI Link: 10.1186/1477-5751-4-9
eISSN: 1477-5751
Links: http://hdl.handle.net/2381/25479
http://jnrbm.biomedcentral.com/articles/10.1186/1477-5751-4-9
Type: Journal Article
Rights: © 2005 Hollox et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Genetics

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