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|Title:||Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.|
|Authors:||Hollox, Edward J.|
Alton, E. W.
Armour, J. A.
|Citation:||Journal of Negative Results in BioMedicine, 2005, 4, pp. 9-9|
|Abstract:||Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy number between 2 and 12 in different individuals. We determined the copy number of this locus in 355 patients with cystic fibrosis (CF), and tested for correlation between beta-defensin cluster genomic copy number and lung disease associated with CF. No significant association was found.|
|Rights:||© 2005 Hollox et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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