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|Title:||The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.|
|Citation:||FEBS LETT, 2010, 584 (11), pp. 2237-2241|
|Abstract:||Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. Its rod region consists of a series of helical bundles. Here we show that residues 1815-1973 form a 5-helix bundle, with a topology unique to talin which is optimally suited for formation of a long rod such as talin. This is much more stable than the 4-helix (1843-1973) domain described earlier and as a result its vinculin binding sequence is inaccessible to vinculin at room temperature, with implications for the overall mechanism of the talin-vinculin interaction.|
|Appears in Collections:||Published Articles, Dept. of Biochemistry|
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