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Title: Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis
Authors: Hirst, Robert A.
Gosai, Bejal
Rutman, Andrew
Andrew, Peter W.
O'Callaghan, Christopher L.
First Published: Oct-2003
Publisher: American Society for Microbiology
Citation: Infection and Immunity, 2003, 71(10), pp.6095-6100
Abstract: Streptococcus pneumoniae meningitis remains a disease with a poor outcome for the patient. A region of the brain that has been neglected in the study of meningitis is the ependyma, which has been identified as a location of adult pluripotent cells. In this study we have used a rat model of meningitis to examine whether the ependymal layer is affected by S. pneumoniae. The effects included localized loss of cilia, a decrease of the overall ependymal ciliary beat frequency, and damage to the ependymal ultrastructure during meningitis. In conclusion, loss of ependymal cells and ciliary function exposes the underlying neuronal milieu to host and bacterial cytotoxins and this is likely to contribute to the neuropathology commonly observed in pneumococcal meningitis.
Type: Article
Description: Copyright © 2003, American Society for Microbiology. Also available from the publisher website at
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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