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Title: Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody
Authors: Hirst, Robert A.
Mohammed, Bashir J.
Mitchell, Timothy J.
Andrew, Peter W.
O'Callaghan, Christopher L.
First Published: Nov-2004
Publisher: American Society for Microbiology
Citation: Infection and Immunity, 2004, 72(11), pp.6694-6698
Abstract: Ciliated ependymal cells line the ventricular surfaces and aqueducts of the brain. In ex vivo experiments, pneumolysin caused rapid inhibition of the ependymal ciliary beat frequency and caused ependymal cell disruption. Wild-type pneumococci and pneumococci deficient in pneumolysin caused ciliary slowing, but penicillin lysis of wild-type, not pneumolysin-deficient, pneumococci increased the extent of ciliary inhibition. This effect was abolished by antipneumolysin antibody. Ependymal ciliary stasis by purified pneumolysin was also blocked by the addition of antipneumolysin monoclonal antibodies. These data show that antibiotic lysis of Streptococcus pneumoniae can be detrimental to the ciliated ependyma and that antipneumolysin antibody may have a therapeutic potential.
Type: Article
Description: Copyright © 2004, American Society for Microbiology. All Rights Reserved. Also available from the publisher website at
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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