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Title: A mammalian mitochondrial serine transfer RNA lacking the “dihydrouridine” loop and stem
Authors: Debruijn, M. H. L.
Schreier, P. H.
Eperon, I. C.
Barrell, B. G.
Chen, E. Y.
Armostrong, P. W.
Wong, J. F. H.
Roe, B. A.
First Published: 1-Jan-1980
Publisher: Oxford University Press (OUP)
Citation: Nucleic Acids Research, 1980, 8 (22), pp. 5213-5222
Abstract: A unique transfer DNA has been identified in human and bovine mitochondria that lacks the “dihydrouridine” loop and stem structure. This tRNA ie mitochondrially coded as shown by DNA sequence analysis of the human and bovine mitochondrial DNA. Sequence analysis of the INA shows that it is post-transcriptionally modified by the addition of CCA at the 3′ terminus and that at least one base is modified. As predicted by its anticodon (GCU, corresponding to the serine codons AGU/C) this tRNA can be aminoacylated with serine when purified mitochondria are incubated in a medium containing [superscript: 3]H-serine.
DOI Link: 10.1093/nar/8.22.5213
ISSN: 0305-1048
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Biochemistry

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