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Title: Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex.
Authors: Atkinson, RA
Joseph, C
Kelly, G
Muskett, FW
Frenkiel, TA
Nietlispach, D
Pastore, A
First Published: Oct-2001
Citation: NAT STRUCT BIOL, 2001, 8 (10), pp. 853-857
Abstract: The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of alpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complex is in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present in the Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains.
DOI Link: 10.1038/nsb1001-853
ISSN: 1072-8368
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Biochemistry

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