Leicester Research Archive

Leicester Research Archive >
College of Science and Engineering >
Engineering, Department of >
Published Articles, Dept. of Engineering >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/27091

Title: Mechanisms contributing to central excitability changes during hearing loss.
Authors: Pilati, N
Ison, MJ
Barker, M
Mulheran, M
Large, CH
Forsythe, ID
Matthias, J
Hamann, M
Issue Date: 22-May-2012
Citation: PROC NATL ACAD SCI U S A, 2012, 109 (21), pp. 8292-8297
Abstract: Exposure to loud sound causes cochlear damage resulting in hearing loss and tinnitus. Tinnitus has been related to hyperactivity in the central auditory pathway occurring weeks after loud sound exposure. However, central excitability changes concomitant to hearing loss and preceding those periods of hyperactivity, remain poorly explored. Here we investigate mechanisms contributing to excitability changes in the dorsal cochlear nucleus (DCN) shortly after exposure to loud sound that produces hearing loss. We show that acoustic overexposure alters synaptic transmission originating from the auditory and the multisensory pathway within the DCN in different ways. A reduction in the number of myelinated auditory nerve fibers leads to a reduced maximal firing rate of DCN principal cells, which cannot be restored by increasing auditory nerve fiber recruitment. In contrast, a decreased membrane resistance of DCN granule cells (multisensory inputs) leads to a reduced maximal firing rate of DCN principal cells that is overcome when additional multisensory fibers are recruited. Furthermore, gain modulation by inhibitory synaptic transmission is disabled in both auditory and multisensory pathways. These cellular mechanisms that contribute to decreased cellular excitability in the central auditory pathway are likely to represent early neurobiological markers of hearing loss and may suggest interventions to delay or stop the development of hyperactivity that has been associated with tinnitus.
DOI Link: 10.1073/pnas.1116981109
eISSN: 1091-6490
Links: http://hdl.handle.net/2381/27091
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Engineering

Files in This Item:

There are no files associated with this item.

View Statistics

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

MAINTAINER