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Title: Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects.
Authors: Thapar, A
Harold, G
Rice, F
Ge, X
Boivin, J
Hay, D
van den Bree M
Lewis, A
First Published: 2007
Citation: BMC MED RES METHODOL, 2007, 7, pp. 25-25
Abstract: There is much evidence to suggest that risk for common clinical disorders begins in foetal life. Exposure to environmental risk factors however is often not random. Many commonly used indices of prenatal adversity (e.g. maternal gestational stress, gestational diabetes, smoking in pregnancy) are influenced by maternal genes and genetically influenced maternal behaviour. As mother provides the baby with both genes and prenatal environment, associations between prenatal risk factors and offspring disease maybe attributable to true prenatal risk effects or to the "confounding" effects of genetic liability that are shared by mother and offspring. Cross-fostering designs, including those that involve embryo transfer have proved useful in animal studies. However disentangling these effects in humans poses significant problems for traditional genetic epidemiological research designs.
DOI Link: 10.1186/1471-2288-7-25
eISSN: 1471-2288
Type: Journal Article
Appears in Collections:Published Articles, School of Psychology

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