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Title: The contribution of gene-environment interaction to psychopathology.
Authors: Thapar, A
Harold, G
Rice, F
Langley, K
O'donovan, M
First Published: 2007
Citation: DEV PSYCHOPATHOL, 2007, 19 (4), pp. 989-1004
Abstract: The study of gene-environment interaction (G x E) constitutes an area of significant social and clinical significance. Different types of research study designs are being used to investigate the contribution of G x E to psychopathology, although the term G x E has also been used and interpreted in different ways. Despite mixed evidence that G x E contributes to psychopathology, some promising and consistent findings are emerging. Evidence is reviewed in relation to depression, antisocial behavior, schizophrenia, and attention-deficit/hyperactivity disorder. Although findings from various research designs have different meaning, interestingly much of the evidence with regard to the contribution of G x E that has arisen from twin and adoption studies has been for antisocial behavior and depression. It is for these same forms of psychopathology that molecular genetic evidence of G x E has also been most convincing. Finally, current and anticipated methodological challenges and implications for future research in this area are considered.
DOI Link: 10.1017/S0954579407000491
ISSN: 0954-5794
Type: Journal Article
Appears in Collections:Published Articles, School of Psychology

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