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|Title: ||How Do Short-Term Changes at Synapses Fine-Tune Information Processing?|
|Authors: ||Klug, Achim|
Borst, J. Gerard G.
Carlson, Bruce A.
Klyachko, Vitaly A.
Xu-Friedman, Matthew A.
|Issue Date: ||10-Oct-2012|
|Publisher: ||Society for Neuroscience|
|Citation: ||Journal of Neuroscience, 2012, 32 (41), pp. 14058-14063.|
|Abstract: ||Synaptic transmission is highly dependent on recent activity and can lead to depression or facilitation of synaptic strength. This phenomenon is called “short-term synaptic plasticity” and is shown at all synapses. While much work has been done to understand the mechanisms of short-term changes in the state of synapses, short-term plasticity is often thought of as a mechanistic consequence of the design of a synapse. This review will attempt to go beyond this view and discuss how, on one hand, complex neuronal activity affects the short-term state of synapses, but also how these dynamic changes in synaptic strength affect information processing in return.|
|DOI Link: ||10.1523/JNEUROSCI.3348-12.2012|
|Version: ||Publisher Version|
|Type: ||Journal Article|
|Rights: ||Copyright © 2012 the authors. Deposited with reference to the publisher's archiving policy available on the SHERPA/RoMEO website. 6 months after publication, the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.|
|Appears in Collections:||Published Articles, MRC Toxicology Unit|
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