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Title: How Do Short-Term Changes at Synapses Fine-Tune Information Processing?
Authors: Klug, Achim
Borst, J. Gerard G.
Carlson, Bruce A.
Kopp-Scheinpflug, Cornelia
Klyachko, Vitaly A.
Xu-Friedman, Matthew A.
First Published: 10-Oct-2012
Publisher: Society for Neuroscience
Citation: Journal of Neuroscience, 2012, 32 (41), pp. 14058-14063.
Abstract: Synaptic transmission is highly dependent on recent activity and can lead to depression or facilitation of synaptic strength. This phenomenon is called “short-term synaptic plasticity” and is shown at all synapses. While much work has been done to understand the mechanisms of short-term changes in the state of synapses, short-term plasticity is often thought of as a mechanistic consequence of the design of a synapse. This review will attempt to go beyond this view and discuss how, on one hand, complex neuronal activity affects the short-term state of synapses, but also how these dynamic changes in synaptic strength affect information processing in return.
DOI Link: 10.1523/JNEUROSCI.3348-12.2012
ISSN: 0270-6474
eISSN: 1529-2401
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2012 the authors. Deposited with reference to the publisher's archiving policy available on the SHERPA/RoMEO website. 6 months after publication, the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.
Appears in Collections:Published Articles, MRC Toxicology Unit

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