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Title: Heart Rate Variability in Low Birth Weight Growth Restricted Children During Sleep and Wake Stages
Authors: Aziz, Wajid
Biala, Taher Ali Said
Habib, Nazneen
Abbasi, Muhammad S.
Wailoo, Michael P.
Schlindwein, Fernando Soares
First Published: 17-Apr-2013
Publisher: Elsevier on behalf of International Measurement Confederation (IMEKO)
Citation: Measurement, 2013, available online in advance of print
Abstract: Poor fetal growth may alter the regularity mechanism of cardiac autonomic system that is involved in the development of these diseases. The malfunctioning of the cardiac autonomic system assessed by decrease in heart rate variability (HRV) is associated with negative cardiovascular outcomes. This study is aimed at investigating the risk of development of coronary heart disease in IUGR children in later life. For that purpose HRV analysis of normal and growth restricted children was performed during sleep and wake stages. The study group consisted of 9 to 10 years old, 32 normal, 20 low birth weight IUGR children. The standard time domain HRV metrics (mean RR, SDNN, RMSSD, NN50 and pNN50) and Poincaré indices (SD1 and SD2) were used to analyse and compare the RR-interval time series of these groups. The IUGR children showed lower HRV as compared with normal children during both sleep and wake stages. The significantly decreased HRV during sleep provide an evidence of autonomic derangement that may be associated with higher risk of lethal arrhythmias in the IUGR children in later life.
DOI Link: 10.1016/j.measurement.2013.04.007
ISSN: 0263-2241
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 Elsevier Ltd. Deposited with reference to the publisher's archiving policy available from the SHERPA/RoMEO website. NOTICE: this is the author’s version of a work that was accepted for publication in Measurement. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication.
Appears in Collections:Published Articles, Dept. of Engineering

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