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Title: The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers
Authors: Tulah, Asif S.
Parker, Stuart G.
Moffatt, Miriam F.
Wardlaw, Andrew J.
Connolly, Martin J.
Sayers, Ian
First Published: 29-Dec-2011
Publisher: BioMed Central Ltd
Citation: BMC Medical Genetics, 2011, 12:173
Abstract: Background: We have previously shown evidence that polymorphisms within genes controlling leukotriene B-4 (LTB[subscript 4]) production (ALOX5AP and LTA4H) are associated with asthma susceptibility in children. Evidence also suggests a potential role of LTB[subscript 4] in COPD disease mechanisms including recruitment of neutrophils to the lung. The aim of the current study was to see if these SNPs and those spanning the receptor genes for LTB[subscript 4] (LTB4R1 and LTB4R2) influence baseline lung function and COPD susceptibility/severity in smokers. Methods: Eight ALOX5AP, six LTA4H and six LTB4R single nucleotide polymorphisms (SNPs) were genotyped in a UK Smoking Cohort (n = 992). Association with baseline lung function (FEV[subscript 1] and FEV[subscript 1]/FVC ratio) was determined by linear regression. Logistic regression was used to compare smoking controls (n = 176) with spirometry-defined COPD cases (n = 599) and to more severe COPD cases (GOLD stage 3 and 4, n = 389). Results: No association with ALOX5AP, LTA4H or LTB4R survived correction for multiple testing. However, we showed modest association with LTA4H rs1978331C (intron 11) with increased FEV[subscript 1] (p = 0.029) and with increased FEV[subscript 1]/FVC ratio (p = 0.020). Conclusions: These data suggest that polymorphisms spanning ALOX5AP, LTA4H and the LTB4R locus are not major determinants of baseline lung function in smokers, but provide tentative evidence for LTA4H rs1978331C (intron 11) in determining baseline FEV[subscript 1] and FEV[subscript 1]/FVC ratio in Caucasian Smokers in addition to our previously identified role in asthma susceptibility.
DOI Link: 10.1186/1471-2350-12-173
eISSN: 1471-2350
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2011 Tulah et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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