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|Title:||Antimicrobial peptides play a functional role in bumblebee anti-trypanosome defense|
Mallon, Eamonn B.
|Publisher:||Elsevier for the International Society of Developmental and Comparative Immunology|
|Citation:||Developmental and Comparative Immunology, in press|
|Abstract:||Bumblebees, amongst the most important of pollinators, are under enormous population pressures. One of these is disease. The bumblebee and its gut trypanosome Crithidia bombi are one of the fundamental models of ecological immunology. Although there is previous evidence of increased immune gene expression upon Crithidia infection, recent work has focussed on the bumblebee’s gut microbiota. Here, by knocking down gene expression using RNAi, we show for the first time that antimicrobial peptides (AMPs) have a functional role in anti-Crithidia defense.|
|Rights:||Copyright © 2013 Elsevier Ltd. All rights reserved. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.|
|Description:||NOTICE: this is the author’s version of a work that was accepted for publication in Developmental and Comparative Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Developmental and Comparative Immunology, [in press] DOI#10.1016/j.dci.2013.09.004.|
|Appears in Collections:||Published Articles, Dept. of Biology|
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