Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/28296
Title: Circadian Regulation of the Na[superscript +]/K[superscript +]-Atpase Alpha Subunit in the Visual System Is Mediated by the Pacemaker and by Retina Photoreceptors in Drosophila Melanogaster
Authors: Damulewicz, Milena
Rosato, Ezio
Pyza, Elzbieta
First Published: 10-Sep-2013
Publisher: Public Library of Science
Citation: PLoS ONE, 2013, 8 (9), e73690
Abstract: We investigated the diurnal oscillation in abundance of the catalytic α subunit of the sodium/potassium pump (ATPα) in the brain of Drosophila melanogaster. This rhythm is bimodal and is particularly robust in the glia cells of the lamina, the first optic neuropil. We observed loss of ATPα cycling in lamina glia in behaviourally arrhythmic per and tim mutants and in flies overexpressing the pro-apoptotic gene hid in the PDF-positive clock neurons. Moreover, the rhythm of ATPα abundance was altered in cry and Pdf mutants, in flies with a weakened clock mechanism in retina photoreceptor cells and in those subject to downregulation of the neuropeptide ITP by RNAi. This complex, rhythmic regulation of the α subunit suggests that the sodium/potassium pump may be a key target of the circadian pacemaker to impose daily control on brain activities, such as rhythmic changes in neuronal plasticity, which are best observed in the visual system.
DOI Link: 10.1371/journal.pone.0073690
eISSN: 1932-6203
Links: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0073690
http://hdl.handle.net/2381/28296
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 Damulewicz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Genetics

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