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Title: TIS11 family proteins and their roles in posttranscriptional gene regulation
Authors: Baou, Maria
Jewell, Andrew
Murphy, John J.
First Published: 2009
Publisher: Hindawi Publishing Corporation
Citation: Journal of Biomedicine and Biotechnology, Volume 2009, Article ID 634520
Abstract: Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their 3' untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases.
DOI Link: 10.1155/2009/634520
ISSN: 1110-7243
eISSN: 1110-7251
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2009 Maria Baou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, MRC Toxicology Unit

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