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|Title:||Real-time multi-marker measurement of organic compounds in human breath : towards fingerprinting breath.|
|Authors:||White, Iain R.|
Willis, Kerry A.
Blake, Robert S.
Wardlaw, Andrew J.
Ellis, Andrew M.
Monks, Paul S.
|Publisher:||Institute of Physics (IOP)|
|Citation:||Journal of Breath Research, 2013, 7 (1), 017112|
|Abstract:||The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.|
|Rights:||Copyright © 2013, IOP Publishing Ltd. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.|
|Appears in Collections:||Published Articles, Dept. of Chemistry|
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|Realtime_MultiMarker measurement_of_Breath_final.pdf||Post-review (final submitted)||1.72 MB||Unknown||View/Open|
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