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Title: Real-time multi-marker measurement of organic compounds in human breath : towards fingerprinting breath.
Authors: White, Iain R.
Willis, Kerry A.
Whyte, Chris
Cordell, Rebecca
Blake, Robert S.
Wardlaw, Andrew J.
Grigg, J.
Ellis, Andrew M.
Monks, Paul S.
Rao, S.
First Published: 27-Feb-2013
Publisher: Institute of Physics (IOP)
Citation: Journal of Breath Research, 2013, 7 (1), 017112
Abstract: The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.
DOI Link: 10.1088/1752-7155/7/1/017112
ISSN: 1752-7155
eISSN: 1752-7163
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013, IOP Publishing Ltd. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Chemistry

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