Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/28662
Title: CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans
Authors: Aklillu, Eleni
Odenthal-Hesse, Linda
Bowdrey, Jennifer
Habtewold, Abiy
Ngaimisi, Eliford
Yimer, Getnet
Amogne, Wondwossen
Mugusi, Sabina
Minzi, Omary
Makonnen, Eyasu
Janabi, Mohammed
Mugusi, Ferdinand
Aderaye, Getachew
Hardwick, Robert
Fu, Beiyuan
Viskaduraki, Maria
Yang, Fengtang
Hollox, Edward J.
First Published: 12-Nov-2013
Publisher: BioMed Central
Citation: BMC Infectious Diseases, 2013, 13:536
Abstract: Background: The role of copy number variation of the CCL3L1 gene, encoding MIP1α, in contributing to the host variation in susceptibility and response to HIV infection is controversial. Here we analyse a sub-Saharan African cohort from Tanzania and Ethiopia, two countries with a high prevalence of HIV-1 and a high co-morbidity of HIV with tuberculosis. Methods: We use a form of quantitative PCR called the paralogue ratio test to determine CCL3L1 gene copy number in 1134 individuals and validate our copy number typing using array comparative genomic hybridisation and fiber-FISH. Results: We find no significant association of CCL3L1 gene copy number with HIV load in antiretroviral-naïve patients prior to initiation of combination highly active anti-retroviral therapy. However, we find a significant association of low CCL3L1 gene copy number with improved immune reconstitution following initiation of highly active anti-retroviral therapy (p = 0.012), replicating a previous study. Conclusions: Our work supports a role for CCL3L1 copy number in immune reconstitution following antiretroviral therapy in HIV, and suggests that the MIP1α -CCR5 axis might be targeted to aid immune reconstitution.
DOI Link: 10.1186/1471-2334-13-536
eISSN: 1471-2334
Links: http://www.biomedcentral.com/1471-2334/13/536
http://hdl.handle.net/2381/28662
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 Aklillu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Genetics

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