Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/28714
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dc.contributor.authorRigatti, Roberto-
dc.contributor.authorJia, Jian-Hua-
dc.contributor.authorSamani, Nilesh J.-
dc.contributor.authorEperon, Ian C.-
dc.date.accessioned2014-03-26T14:30:16Z-
dc.date.available2014-03-26T14:30:16Z-
dc.date.issued2004-
dc.identifier.citationNucleic Acids Research, 2004, 32 (2), pp. 441-446en
dc.identifier.issn0305-1048-
dc.identifier.urihttp://nar.oxfordjournals.org/content/32/2/441en
dc.identifier.urihttp://hdl.handle.net/2381/28714-
dc.description.abstractExon repetition describes the presence of tandemly repeated exons in mRNA in the absence of duplications in the genome. Its existence challenges our understanding of gene expression, because the linear organization of sequences in apparently normal genes must be subverted during RNA synthesis or processing. It is restricted to a small number of genes in some of which over half of the mRNA contains specific patterns of repetition. Although it is sometimes assumed to arise by trans-splicing, there is no evidence of this and the efficiency is very much higher than for examples of bona fide trans-splicing in mammals. Furthermore, a potentially ubiquitous reaction such as trans-splicing is not consistent with a phenomenon that involves such a high proportion of the products of so few genes. Instead, it seems more probable that exon repetition is caused by a specific trans-acting factor. We have tested this and demonstrate for the two best characterized examples that the property is restricted to specific alleles of the affected genes and is determined in cis. It is not determined by exonic splicing signals, as had been suggested previously. In heterozygotes, RNA transcribed from the two alleles of an affected gene can have fundamentally different fates.en
dc.language.isoenen
dc.publisherOxford University Press (OUP)en
dc.relation.replaceshttp://hdl.handle.net/2381/14498en
dc.relation.replaces2381/14498en
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/14739236-
dc.rightsCopyright © 2004, Oxford University Press (OUP). Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.en
dc.sourceScopus-
dc.source.urihttp://www.scopus.com/home.url-
dc.subjectAllelesen
dc.subjectAnimalsen
dc.subjectExonsen
dc.subjectHeterozygoteen
dc.subjectModels, Geneticen
dc.subjectMolecular Sequence Dataen
dc.subjectProteinsen
dc.subjectRNA Precursorsen
dc.subjectRNA Processing, Post-Transcriptionalen
dc.subjectRNA Splice Sitesen
dc.subjectRNA, Messengeren
dc.subjectRatsen
dc.subjectRats, Inbred SHRen
dc.subjectRats, Inbred WKYen
dc.subjectRegulatory Sequences, Ribonucleic Aciden
dc.subjectRepetitive Sequences, Nucleic Aciden
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.subjectTrans-Splicingen
dc.titleExon repetition : a major pathway for processing mRNA of some genes is allele-specificen
dc.typeJournal Articleen
dc.identifier.doi10.1093/nar/gkh197-
dc.identifier.eissn1362-4962-
dc.identifier.pii32/2/441-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciences/Department of Biochemistryen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Canceren
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Genome Scienceen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Molecular & Cellular Bioscienceen
dc.description.irispid14111-
Appears in Collections:Published Articles, Dept. of Biochemistry

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