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Title: Wiring the olfactory bulb -- activity - dependent models of axonal targeting in the developing olfactory pathway
Authors: Gill, Daljeet S.
Pearce, Timothy Charles
First Published: 11-May-2011
Publisher: De Gruyter
Citation: Reviews in the Neurosciences, 2003, 14 (1-2), pp. 63-72
Abstract: Two recent experimental studies /20,21/ revealed that odorant-evoked activity-dependent competition is significant in the organisation and maintenance of the olfactory system. In this paper, we investigate the generation of a chemotopic sensory map in the olfactory bulb through three models driven by high-density optical chemosensor arrays which have similar properties to olfactory receptor neurons. By exposing the sensor arrays to various odours, these models were subjected to Hebbian learning to achieve self-organisation, potentially explaining the activity-dependent competition demonstrated by these recent studies. Our final model also predicts a role for periglomerular cells in the formation of the chemotopic sensory map in the olfactory bulb.
DOI Link: 10.1515/REVNEURO.2003.14.1-2.63
ISSN: 0334-1763
eISSN: 2191-0200
Type: Journal Article
Description: Full text of this item is not currently available on the LRA. The final published version may be available through the links above.
Appears in Collections:Published Articles, Dept. of Engineering

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