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|Title:||Wiring the olfactory bulb -- activity - dependent models of axonal targeting in the developing olfactory pathway|
|Authors:||Gill, Daljeet S.|
Pearce, Timothy Charles
|Citation:||Reviews in the Neurosciences, 2003, 14 (1-2), pp. 63-72|
|Abstract:||Two recent experimental studies /20,21/ revealed that odorant-evoked activity-dependent competition is significant in the organisation and maintenance of the olfactory system. In this paper, we investigate the generation of a chemotopic sensory map in the olfactory bulb through three models driven by high-density optical chemosensor arrays which have similar properties to olfactory receptor neurons. By exposing the sensor arrays to various odours, these models were subjected to Hebbian learning to achieve self-organisation, potentially explaining the activity-dependent competition demonstrated by these recent studies. Our final model also predicts a role for periglomerular cells in the formation of the chemotopic sensory map in the olfactory bulb.|
|Description:||Full text of this item is not currently available on the LRA. The final published version may be available through the links above.|
|Appears in Collections:||Published Articles, Dept. of Engineering|
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