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Title: Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues
Authors: McCutcheon, James E.
Beeler, Jeff A.
Roitman, Mitchell F.
First Published: 29-Dec-2011
Publisher: Wiley for Wiley-Liss
Citation: Synapse, 2012, 66 (4), pp. 346-351
Abstract: Cues that have been paired with food evoke dopamine in nucleus accumbens (NAc) and drive approach behavior. This cue-evoked dopamine signaling could contribute to overconsumption of food. One manner in which individuals try to restrict caloric intake is through the consumption of foods containing artificial (non-nutritive) sweeteners. We were interested in whether cues paired with a non-nutritive sweetener (saccharin) would evoke similar dopamine release as cues paired with a nutritive sweetener (sucrose). We trained food-restricted rats to associate distinct cues with sucrose or saccharin pellets. In the first group of rats, training sessions with each pellet took place on different days, maximizing the opportunity for rats to detect nutritional differences. After training, voltammetry recordings in NAc core revealed that sucrose cues evoked greater phasic dopamine release than saccharin cues. In a second group of rats, on each training day, sucrose and saccharin pellets were presented in pseudorandom order within the same session, to mask nutritional differences. In this condition, the difference in dopamine between sucrose and saccharin cues was attenuated, but not abolished. These results suggest that sucrose-paired cues will more powerfully motivate behavior than saccharin-paired cues. The differing responses to each cue seem to be driven by overall preference with both the nutritional value that the pellets predict as well as other factors, such as taste, contributing.
DOI Link: 10.1002/syn.21519
ISSN: 0887-4476
eISSN: 1098-2396
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2012, Wiley for Wiley-Liss. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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McCutcheon R1 Fig 1_final.tifPost-review (final submitted)18.49 MBTIFFView/Open
McCutcheon R1 Fig 2_final.tifPost-review (final submitted)4.32 MBTIFFView/Open
McCutcheon et al_R1 Synapse FINAL.pdfPost-review (final submitted)586.13 kBAdobe PDFView/Open

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