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Title: Heterogeneity of dopamine neuron activity across traits and states
Authors: Marinelli, M.
McCutcheon, James E.
First Published: 30-Jul-2014
Publisher: Elsevier
Citation: Neuroscience, 2014, 282, pp. 176-197
Abstract: Midbrain dopamine neurons fire irregularly, with interspersed clusters of high-frequency spikes, commonly called ‘bursts’. In this review we examine such heterogeneity in activity, and provide insight into how it can participate in psychiatric conditions such as drug addiction. We first describe several techniques used to evaluate dopamine neuron activity, and comment on the different measures that each provides. We next describe the activity of dopamine neurons in ‘basal’ conditions. Specifically, we discuss how the use of anesthesia and reduced preparations may alter aspects of dopamine cell activity, and how there is heterogeneity across species and regions. We also describe how dopamine cell firing changes throughout the peri-adolescent period and how dopamine neuron activity differs across the population. In the final section, we discuss how dopamine neuron activity changes in response to life events. First, we focus attention on drugs of abuse. Drugs themselves change firing activity through a variety of mechanisms, with effects on firing while drug is present differing from those seen after drug discontinuation. We then review how stimuli that are rewarding, aversive, or salient can evoke changes in firing rate and discharge pattern of dopamine neurons, and provide behavioral relevance of dopamine signaling. Finally, we discuss how stress can modulate dopamine neuron firing and how this may contribute to the role that stressful experiences play in psychiatric disorders such as addiction and depression.
DOI Link: 10.1016/j.neuroscience.2014.07.034
ISSN: 0306-4522
eISSN: 1873-7544
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014, Elsevier. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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Marinelli & McCutcheon_R1_v4.pdfPost-review (final submitted)397.78 kBAdobe PDFView/Open

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