Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/29113
Title: Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body
Authors: Jalabi, Walid
Kopp-Scheinpflug, Cornelia
Allen, Paul D.
Schiavon, Emanuele
DiGiacomo, Rita R.
Forsythe, Ian D.
Maricich, Stephen M.
First Published: 18-Sep-2013
Publisher: Society for Neuroscience
Citation: Journal of Neuroscience, 2013, 33 (38), pp. 15044-15049
Abstract: The medial nucleus of the trapezoid body (MNTB) in the superior olivary complex (SOC) is an inhibitory hub considered critical for binaural sound localization. We show that genetic ablation of MNTB neurons in mice only subtly affects this ability by prolonging the minimum time required to detect shifts in sound location. Furthermore, glycinergic innervation of the SOC is maintained without an MNTB, consistent with the existence of parallel inhibitory inputs. These findings redefine the role of MNTB in sound localization and suggest that the inhibitory network is more complex than previously thought.
DOI Link: 10.1523/JNEUROSCI.2604-13.2013
ISSN: 0270-6474
eISSN: 1529-2401
Links: http://www.jneurosci.org/content/33/38/15044
http://hdl.handle.net/2381/29113
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013, Society for Neuroscience. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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