Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/29196
Title: Quantitative electroencephalography as a biomarker for proneness toward developing psychosis
Authors: Fuggetta, Giorgio
Bennett, Matthew A.
Duke, Philip A.
Young, Andrew M. J.
First Published: 6-Feb-2014
Publisher: Elsevier for Schizophrenia International Research Society
Citation: Schizophrenia Research, 2014, 153 (1-3), pp. 68-77
Abstract: The fully dimensional approach to the relationship between schizotypal personality traits and schizophrenia describes schizotypy as a continuum throughout the general population ranging from low schizotypy (LoS) and psychological health to high schizotypy (HiS) and psychosis-proneness. However, no biological markers have yet been discovered that reliably quantify an individual's degree of schizotypy and/or psychosis. This study aimed to evaluate quantitative electroencephalographic (qEEG) measures of power spectra as potential biomarkers of the proneness towards the development of psychosis in schizotypal individuals. The resting-state oscillatory brain dynamics under eyes-closed condition from 16 LoS and 16 HiS individuals were analysed for qEEG measures of background rhythm frequency, relative power in δ, θ, low-α, high-α, low-β, high-β and low-γ frequency bands, and the high-temporal cross-correlation of power spectra between low- and high-frequency bands observed by averaging signals from whole-head EEG electrodes. HiS individuals at rest locked the thalamocortical loop in the low-α band at a lower-frequency oscillation and displayed an abnormally high level of neural synchronisation. In addition, the high-α band was found to be positively correlated with both the high-β and low-γ bands unlike LoS individuals, indicating widespread thalamocortical resonance in HiS individuals. The increase of regional alpha oscillations in HiS individuals suggests abnormal high-level attention, whereas the pattern of correlation between frequency bands resembles the thalamocortical dysrhythmia phenomenon which underlies the symptomatology of a variety of neuropsychiatric disorders including schizophrenia. These qEEG biomarkers may aid clinicians in identifying HiS individuals with a high-risk of developing psychosis.
DOI Link: 10.1016/j.schres.2014.01.021
ISSN: 0920-9964
eISSN: 1573-2509
Links: http://www.sciencedirect.com/science/article/pii/S0920996414000449
http://hdl.handle.net/2381/29196
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014, Elsevier. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Description: The file associated with this record is embargoed until 12 months after the date of publication. The final published version may be available through the links above.
Appears in Collections:Published Articles, School of Psychology

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