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Title: Meiotic adaptation to genome duplication in Arabidopsis arenosa
Authors: Yant, L.
Hollister, J. D.
Wright, K. M.
Arnold, B. J.
Higgins, James D.
Franklin, F. Chris H.
Bomblies, K.
First Published: 17-Oct-2013
Publisher: Elsevier (Cell Press)
Citation: Current Biology, 2013, 23, pp. 2151-2156 (6)
Abstract: Whole genome duplication (WGD) is a major factor in the evolution of multicellular eukaryotes, yet by doubling the number of homologs, WGD severely challenges reliable chromosome segregation, a process conserved across kingdoms. Despite this, numerous genome-duplicated (polyploid) species persist in nature, indicating early prob- lems can be overcome. Little is known about which genes are involved—only one has been molecularly charac- terized. To gain new insights into the molecular basis of adaptation to polyploidy, we investigated genome-wide patterns of differentiation between natural diploids and tetraploids of Arabidopsis arenosa, an outcrossing relative of A. thaliana. We first show that diploids are not preadapted to polyploid meiosis. We then use a genome scanning approach to show that although polymorphism is extensively shared across ploidy levels, there is strong ploidy-specific differentiation in 39 regions spanning 44 genes. These are discrete, mostly single-gene peaks of sharply elevated differentiation. Among these peaks are eight meiosis genes whose encoded proteins coordinate a specific subset of early meiotic functions, suggesting these genes comprise a polygenic solution to WGD-associated chromosome segregation challenges. Our findings indicate that even conserved meiotic processes can be capable of nimble evolutionary shifts when required.
DOI Link: 10.1016/j.cub.2013.08.059
ISSN: 0960-9822
eISSN: 1879-0445
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Archived with reference to SHERPA/RoMEO and publisher website. Journal of record:
Description: Supplemental Information includes Supplemental Experimental Procedures and six tables and can be found with this article online at 10.1016/j.cub.2013.08.059
Appears in Collections:Published Articles, Dept. of Biology

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