Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/31651
Title: Infants born late/moderately preterm are at increased risk for a positive autism screen at 2 years of age.
Authors: Guy, Alexa
Seaton, Sarah E.
Boyle, Elaine M.
Draper, Elizabeth S.
Field, David J.
Manktelow, Bradley N.
Marlow, N.
Smith, Lucy K.
Johnson, Samantha
First Published: Feb-2015
Citation: The Journal of Pediatrics, 2015, 166 (2), pp. 269-275.e3
Abstract: Objectives To assess the prevalence of positive screens using the Modified Checklist for Autism in Toddlers (M-CHAT) questionnaire and follow-up interview in late and moderately preterm (LMPT; 32-36 weeks) infants and term-born controls. Study design Population-based prospective cohort study of 1130 LMPT and 1255 term-born infants. Parents completed the M-CHAT questionnaire at 2-years corrected age. Parents of infants with positive questionnaire screens were followed up with a telephone interview to clarify failed items. The M-CHAT questionnaire was rescored, and infants were classified as true or false positives. Neurosensory, cognitive, and behavioral outcomes were assessed using parent report. Results Parents of 634 (57%) LMPT and 761 (62%) term-born infants completed the M-CHAT questionnaire. LMPT infants had significantly higher risk of a positive questionnaire screen compared with controls (14.5% vs 9.2%; relative risk [RR] 1.58; 95% CI 1.18, 2.11). After follow-up, significantly more LMPT infants than controls had a true positive screen (2.4% vs 0.5%; RR 4.52; 1.51, 13.56). This remained significant after excluding infants with neurosensory impairments (2.0% vs 0.5%; RR 3.67; 1.19, 11.3). Conclusions LMPT infants are at significantly increased risk for positive autistic screen. An M-CHAT follow-up interview is essential as screening for autism spectrum disorders is especially confounded in preterm populations. Infants with false positive screens are at risk for cognitive and behavioral problems. (J Pediatr 2015;166:269-75).
DOI Link: 10.1016/j.jpeds.2014.10.053
ISSN: 0022-3476
eISSN: 1097-6833
Links: http://www.sciencedirect.com/science/article/pii/S0022347614010208
http://hdl.handle.net/2381/31651
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/3.0/)
Appears in Collections:Published Articles, Dept. of Health Sciences

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