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Title: Monitoring human exposure to 2-hydroxyethylating carcinogens
Authors: Farmer, Peter B.
Cordero, Rosa
Autrup, H.
First Published: May-1996
Presented at: 2nd International Conference on Environmental Mutagens in Human Populations held 20-25 August 1995 in Prague, Czech Republic.
Publisher: National Institute of Environmental Health Sciences (NIEHS)
Citation: Environmental Health Perspectives, 1996, 104 (SUPPL. 3), pp. 449-452
Abstract: It is known that human hemoglobin contains low levels of N-terminal N-(2-hydroxyethyl)valine. Possible sources of this modified amino acid are exposure to ethylene oxide or other 2-hydroxyethylating agents. Although such processes are likely to occur endogenously, the exogenous contribution to the adduct formation is unclear. In order to explore the latter, we have analyzed N-(2-hydroxyethyl)valine in the globin of 49 pregnant women and evaluated the effect of smoking status, area of residence, and glutathione S-transferase M1 genotype on adduct levels. Transplacental transfer of hydroxyethylating agents was also studied by the analysis of umbilical cord hemoglobin. The adduct levels in smokers were significantly higher than those in nonsmokers. The adduct levels in umbilical cord blood globin were quantitatively related to those in maternal blood (maternal:fetal ratio 2.7 in smokers and 2.8 in nonsmokers). In the nonsmokers, there was no statistically significant difference in the adduct level between the urban and rural areas, but the level in suburbia tended to be lower than that in the rural area. In the combined smoker and nonsmoker groups, there was no effect of the glutathione S-transferase M1 genotype on levels of N-(2-hydroxyethyl)valine.
DOI Link: 10.2307/3432802
ISSN: 0091-6765
eISSN: 1552-9924
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Reproduced with permission from Environmental Health Perspectives. Version of record:
Description: PMCID: PMC1469654
Appears in Collections:Published Articles, MRC Toxicology Unit

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