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Title: The role of stromal fibroblasts in lung carcinogenesis: a target for chemoprevention?
Authors: Howells, Lynne M.
Mahale, Jagdish
Smagurauskaite, Gintare
Brown, Karen
Thomas, Anne
First Published: 6-Feb-2015
Publisher: Wiley for International Union against Cancer (UICC)
Citation: International Journal of Cancer, 2015
Abstract: The tumour microenvironment plays an essential role in the development and spread of cancers. Tumour cells interact with the surrounding extracellular matrix (ECM), embedded within which, are a variety of non-cancer cells including cells of the vasculature, immune system and fibroblasts. The essential role of fibroblasts in the cultivation and maintenance of an environment in which tumour cells are able to maintain their aggressive phenotypic traits is becoming increasingly well documented. Cancer-associated fibroblasts are able to secrete a vast array of ECM-modulating factors, meaning that they have potential for a functional role in every step of the carcinogenic process. In particular, they are likely to have a role in early tumour-initiating inflammatory events, and so may provide a potential target for chemopreventive intervention. This review summarises the known interactions between lung tumour cells and surrounding reactive fibroblasts, highlighting the need to further investigate cancer-associated fibroblasts as therapeutic targets in lung cancer chemoprevention strategies.
DOI Link: 10.1002/ijc.29447
ISSN: 0020-7136
eISSN: 1097-0215
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, Wiley for International Union against Cancer (UICC). Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Description: This is the accepted version of the following article: Mahale, J., Smagurauskaite, G., Brown, K., Thomas, A. and Howells, L. M. (2015), The role of stromal fibroblasts in lung carcinogenesis: A target for chemoprevention?. Int. J. Cancer. doi: 10.1002/ijc.29447, which has been published in final form at
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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