Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/31929
Title: Differential regulation of insulin-like growth factor binding protein-1 and -2 by insulin in the baboon (Papio anubis) endometrium
Authors: Fleming, S. D.
Fazleabas, A. T.
Bell, Stephen C.
First Published: 31-Jan-2008
Publisher: BioMed Central
Citation: Reproductive Biology and Endocrinology, 2008, 6, pp. ?-? (11)
Abstract: Background The purpose of this study was to examine the effect of insulin on expression and synthesis of IGFBP-1 and IGFBP-2 in the baboon endometrium in vitro. Methods Baboon endometrial explants collected from cycling, ovariectomized, steroid-treated, simulated-pregnant and pregnant animals were cultured for 48 h in the presence or absence of insulin, with or without estradiol, progesterone and hCG. Results Insulin clearly inhibited IGFBP-1 production and mRNA expression in a time- and dose-dependent manner, whereas IGFBP-2 synthesis was not significantly affected. The inhibitory effects of insulin on IGFBP-1 were more evident in explants of non-pregnant tissue or tissue away from the implantation site. In the absence of insulin, synthesis of IGFBP-1 was induced in explants with low levels of de novo synthesis whereas IGFBP-2 synthesis was inhibited. This effect was potentiated by steroids and hCG in the explant cultures. Conclusion Insulin differentially regulates endometrial IGFBP-1 and IGFBP-2 secretion in the baboon.
DOI Link: 10.1186/1477-7827-6-6
ISSN: 1477-7827
eISSN: 1477-7827
Links: http://www.rbej.com/content/6/1/6
http://hdl.handle.net/2381/31929
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: © 2008 Fleming et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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