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Title: Known knowns, known unknowns, and unknown unknowns: can systems medicine provide a new approach to sepsis?
Authors: Thompson, Jonathan P.
Coats, Timothy J
Sims, Mark R.
First Published: 22-Apr-2015
Publisher: Oxford University Press (OUP)
Citation: Br J Anaesth, 2015, doi: 10.1093/bja/aev097
Abstract: "As we know, there are known knowns; there are things we know we know. We also know there are known unknowns; that is to say we know there are some things we do not know. But there are also unknown unknowns—the ones we don’t know we don’t know." Donald Rumsfeld's statement as US Secretary of State for Defense during a news briefing in 2002 attracted much publicity and comment. Despite several decades of laboratory and clinical research, Rumsfeld's assertions can be applied to the current state of knowledge about sepsis, acute illness, and anaesthesia.
DOI Link: 10.1093/bja/aev097
ISSN: 0007-0912
eISSN: 1471-6771
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, OUP. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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