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Title: Association between direct measurement of active serum calcium and risk of type 2 diabetes mellitus: a prospective study
Authors: Zaccardi, Francesco
Webb, D. R.
Carter, P.
Pitocco, D.
Khunti, Kamlesh
Davies, M. J.
Kurl, S.
Laukkanen, J. A.
First Published: 4-Mar-2015
Publisher: Elsevier
Citation: Nutrition Metabolism and Cardiovascular Diseases, 2015, 25 (6), pp 562–568
Abstract: Background and aims: Previous prospective studies showing a positive association between serum calcium and incidence of type 2 diabetes mellitus (T2DM) have relied on total calcium or an indirect estimate of active, ionized calcium (iCa). We aimed to assess this relationship using a direct measurement of iCa. Methods and results: iCa and cardiometabolic risk factors were measured in a population-based sample of 2350 men without a known history of T2DM at baseline. Associations between iCa levels and incident cases of T2DM (self-reported, ascertained with a glucose tolerance test, or determined by record linkage to national registers) were estimated using Cox regression analyses adjusted for potential confounders. At baseline, mean (standard deviation) age was 53 (5) years and mean iCa 1.18 (0.05) mmol/L. During a median follow-up of 23.1 years, 140 new cases of T2DM were recorded. In a multivariable analysis adjusted for age, body mass index, systolic blood pressure, serum HDL-cholesterol, and family history of T2DM, there was no association comparing second (hazard ratio 0.84; 95% confidence interval 0.59–1.18), third (0.77; 0.52–1.14), or fourth (0.98; 0.69–1.39) vs first quartile of iCa (p for trend 0.538); further adjustment for C-reactive protein, physical activity level, and triglycerides did not change the estimates (p for trend 0.389). Conclusion: In this study, we did not find evidence of an association between direct measurement of active calcium and risk of T2DM. Further studies are needed to confirm our findings and define the relationship between factors influencing indirect calcium estimation and incident T2DM.
DOI Link: 10.1016/j.numecd.2015.02.013
ISSN: 0939-4753
eISSN: 1590-3729
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: The post-print version available below is distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License ( ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. The published version of the article is Copyright © 2015, Elsevier. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Health Sciences

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