Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32421
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dc.contributor.authorTauber, Eran-
dc.contributor.authorPegoraro, Mirko-
dc.contributor.authorPicot, Emma-
dc.contributor.authorHansen, Celia N.-
dc.contributor.authorKyriacou, Charalambos P.-
dc.contributor.authorRosato, Ezio-
dc.date.accessioned2015-06-24T10:59:43Z-
dc.date.available2015-06-24T10:59:43Z-
dc.date.issued2015-05-08-
dc.identifier.citationFrontiers in Neurology, 2015, 6 : 100en
dc.identifier.issn1664-2295-
dc.identifier.urihttp://journal.frontiersin.org/article/10.3389/fneur.2015.00100/abstracten
dc.identifier.urihttp://hdl.handle.net/2381/32421-
dc.description.abstractThe circadian clock provides the temporal framework for rhythmic behavioral and metabolic functions. In the modern era of industrialization, work, and social pressures, clock function is jeopardized, and can result in adverse and chronic effects on health. Understanding circadian clock function, particularly individual variation in diurnal phase preference (chronotype), and the molecular mechanisms underlying such chronotypes may lead to interventions that could abrogate clock dysfunction and improve human (and animal) health and welfare. Our preliminary studies suggested that fruit-flies, like humans, can be classified as early rising “larks” or late rising “owls,” providing a convenient model system for these types of studies. We have identified strains of flies showing increased preference for morning emergence (Early or E) from the pupal case, or more pronounced preference for evening emergence (Late or L). We have sampled pupae the day before eclosion (fourth day after pupariation) at 4 h intervals in the E and L strains, and examined differences in gene expression by RNA-seq. We have identified differentially expressed transcripts between the E and L strains, which provide candidate genes for subsequent studies of Drosophila chronotypes and their human orthologs.en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttp://journal.frontiersin.org/article/10.3389/fneur.2015.00100/abstract-
dc.rightsCopyright © the authors, 2015. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectchronotypeen
dc.subjectcircadian clocken
dc.subjectDrosophilaen
dc.subjecteclosionen
dc.subjecttranscriptomicsen
dc.titleGene expression associated with early and late chronotypes in Drosophila melanogasteren
dc.typeJournal Articleen
dc.identifier.doi10.3389/fneur.2015.00100-
dc.identifier.eissn1664-2295-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeArticle-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciences/Department of Geneticsen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Genome Scienceen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Neuroscience & Behaviouren
Appears in Collections:Published Articles, Dept. of Genetics

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