Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32492
Title: Characterisation of Acinar Airspace Involvement in Asthma using Inert Gas Washout and Hyperpolarised 3Helium Magnetic Resonance
Authors: Gonem, Sherif
Hardy, S.
Buhl, N.
Hartley, Ruth
Soares, Marcia
Kay, R.
Costanza, R.
Gustafsson, P.
Brightling, Christopher E.
Owers-Bradley, J.
Siddiqui, Salman
First Published: 2015
Publisher: Elsevier for American Academy of Allergy, Asthma and Immunology, Mosby
Citation: Journal of Allergy and Clinical Immunology
Abstract: Background The multiple breath washout (MBW) parameter Sacin is thought to be a marker of acinar airway involvement, but has not been validated using quantitative imaging techniques in asthma. Objective We aimed to utilise 3He diffusion magnetic resonance ( 3 He-MR) at multiple diffusion timescales and quantitative computed tomography (CT) densitometry to determine the nature of acinar airway involvement in asthma. Methods Thirty-seven patients with asthma and seventeen age-matched healthy controls underwent spirometry, body plethysmography, MBW (using the tracer gas sulphur hexafluoride) and He-MR. A subset of patients with asthma (n = 27) underwent quantitative CT densitometry. Results Ninety-four percent (16/17) of patients with an elevated Sacin had GINA treatment steps 4/5 asthma and 13/17 had refractory disease. The apparent diffusion coefficient (ADC) of 3 He at 1s was significantly higher in patients with Sacin-high asthma compared to healthy controls (0.024 vs 0.017, p < 0.05). Sacin correlated strongly with ADC at 1s (R = 0.65, p < 0.001), but weakly with ADC at 13ms (R = 0.38, p < 0.05). ADC at both 13ms and 1s correlated strongly with the mean lung density expiratory / inspiratory ratio, a CT marker of expiratory air trapping (R = 0.77, p < 0.0001 for ADC at 13ms; R = 0.72, p < 0.001 for ADC at 1s). Conclusion Sacin is associated with alterations in long-range diffusion within the acinar airways and gas trapping. The precise anatomical nature and mechanistic role in severe asthma requires further evaluation.
DOI Link: TBA
ISSN: 0091-6749
eISSN: 1097-6825
Links: TBA
http://hdl.handle.net/2381/32492
Embargo on file until: 1-Jan-10000
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Archived with reference to SHERPA/RoMEO and publisher website. © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ 12 Month embargo
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

Files in This Item:
File Description SizeFormat 
JACI-D-14-01415R3.pdfPost-review (final submitted)710.16 kBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.