Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32572
Title: Quantitative assessment of carotid plaque surface irregularities and correlation to cerebrovascular symptoms
Authors: Kanber, Baris
Hartshorne, Timothy C.
Horsfield, Mark A.
Naylor, Andrew R.
Robinson, Thompson G.
Ramnarine, K. V.
First Published: 6-Nov-2013
Publisher: BioMed Central
Citation: Cardiovascular Ultrasound, 2013, 11 : 38
Abstract: Background: The purpose of this study was to determine whether surface irregularities measured from ultrasound images of carotid artery plaques and quantified using a novel method, correlate with the presence of ipsilateral hemispheric cerebrovascular symptoms. Methods: A plaque surface irregularity index (SII) was measured in 47 carotid artery plaques (32 subjects, stenosis range 10% -95%, 49% symptomatic) using ultrasound image sequences spanning several cardiac cycles. The differences in the distribution of SII in plaques with ipsilateral hemispheric symptoms versus those without symptoms and the correlation between the SII of plaques and the degrees of stenosis of the corresponding arteries were assessed. Diagnostic performance of plaque SII was evaluated on its own and in combination with the degree of stenosis. Results: The mean SII was significantly greater for plaques with ipsilateral hemispheric symptoms (1.89 radians/mm) than for asymptomatic plaques (1.67 radians/mm, p = 0.03). There was no statistically significant association between the SII and the degree of stenosis (p = 0.30). SII predicted the presence of cerebrovascular symptoms with an accuracy of 66% (sensitivity 65%, specificity 67%) on its own and with an accuracy of 83% (sensitivity 96%, specificity 71%) in combination with the degree of stenosis. Conclusions: Quantitative assessment of carotid plaque surface irregularities using a novel SII parameter correlates with the presence ipsilateral hemispheric cerebrovascular symptoms and may increase diagnostic performance beyond that provided by the degree of stenosis.
DOI Link: 10.1186/1476-7120-11-38
eISSN: 1476-7120
Links: http://www.cardiovascularultrasound.com/content/11/1/38
http://hdl.handle.net/2381/32572
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 Kanber et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description: PMCID: PMC4228278
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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