Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32572
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dc.contributor.authorKanber, Baris-
dc.contributor.authorHartshorne, Timothy C.-
dc.contributor.authorHorsfield, Mark A.-
dc.contributor.authorNaylor, Andrew R.-
dc.contributor.authorRobinson, Thompson G.-
dc.contributor.authorRamnarine, K. V.-
dc.date.accessioned2015-07-10T10:21:16Z-
dc.date.available2015-07-10T10:21:16Z-
dc.date.issued2013-11-06-
dc.identifier.citationCardiovascular Ultrasound, 2013, 11 : 38en
dc.identifier.urihttp://www.cardiovascularultrasound.com/content/11/1/38en
dc.identifier.urihttp://hdl.handle.net/2381/32572-
dc.descriptionPMCID: PMC4228278en
dc.description.abstractBackground: The purpose of this study was to determine whether surface irregularities measured from ultrasound images of carotid artery plaques and quantified using a novel method, correlate with the presence of ipsilateral hemispheric cerebrovascular symptoms. Methods: A plaque surface irregularity index (SII) was measured in 47 carotid artery plaques (32 subjects, stenosis range 10% -95%, 49% symptomatic) using ultrasound image sequences spanning several cardiac cycles. The differences in the distribution of SII in plaques with ipsilateral hemispheric symptoms versus those without symptoms and the correlation between the SII of plaques and the degrees of stenosis of the corresponding arteries were assessed. Diagnostic performance of plaque SII was evaluated on its own and in combination with the degree of stenosis. Results: The mean SII was significantly greater for plaques with ipsilateral hemispheric symptoms (1.89 radians/mm) than for asymptomatic plaques (1.67 radians/mm, p = 0.03). There was no statistically significant association between the SII and the degree of stenosis (p = 0.30). SII predicted the presence of cerebrovascular symptoms with an accuracy of 66% (sensitivity 65%, specificity 67%) on its own and with an accuracy of 83% (sensitivity 96%, specificity 71%) in combination with the degree of stenosis. Conclusions: Quantitative assessment of carotid plaque surface irregularities using a novel SII parameter correlates with the presence ipsilateral hemispheric cerebrovascular symptoms and may increase diagnostic performance beyond that provided by the degree of stenosis.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/24195596-
dc.rightsCopyright © 2013 Kanber et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAgeden
dc.subjectCarotid Arteriesen
dc.subjectCarotid Stenosisen
dc.subjectCerebrovascular Disordersen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectReproducibility of Resultsen
dc.subjectSensitivity and Specificityen
dc.subjectSeverity of Illness Indexen
dc.subjectStatistics as Topicen
dc.subjectUltrasonographyen
dc.titleQuantitative assessment of carotid plaque surface irregularities and correlation to cerebrovascular symptomsen
dc.typeJournal Articleen
dc.identifier.doi10.1186/1476-7120-11-38-
dc.identifier.eissn1476-7120-
dc.identifier.pii1476-7120-11-38-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeEvaluation Studies;Journal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Neuroscience & Behaviouren
dc.dateaccepted2013-11-04-
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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