Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32574
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dc.contributor.authorEvans, M.-
dc.contributor.authorKhunti, Kamlesh-
dc.contributor.authorMamdani, M.-
dc.contributor.authorGalbo-Jørgensen, C. B.-
dc.contributor.authorGundgaard, J.-
dc.contributor.authorBøgelund, M.-
dc.contributor.authorHarris, S.-
dc.date.accessioned2015-07-10T10:35:44Z-
dc.date.available2015-07-10T10:35:44Z-
dc.date.issued2013-06-03-
dc.identifier.citationHealth Qual Life Outcomes, 2013, 11 : 90en
dc.identifier.urihttp://www.hqlo.com/content/11/1/90en
dc.identifier.urihttp://hdl.handle.net/2381/32574-
dc.description.abstractBACKGROUND: Hypoglycaemic events, particularly nocturnal, affect health-related quality of life (HRQoL) via acute symptoms, altered behaviour and fear of future events. We examined the respective disutility associated with a single event of daytime, nocturnal, severe and non-severe hypoglycaemia. METHODS: Representative samples were taken from Canada, Germany, Sweden, the United States and the United Kingdom. Individuals completed an internet-based questionnaire designed to quantify the HRQoL associated with different diabetes- and/or hypoglycaemia-related health states. HRQoL was measured on a utility scale: 1 (perfect health) to 0 (death) using the time trade-off method. Three populations were studied: 8286 respondents from the general population; 551 people with type 1 diabetes; and 1603 with type 2 diabetes. Respondents traded life expectancy for improved health states and evaluated the health states of well-controlled diabetes and diabetes with non-severe/severe and daytime/nocturnal hypoglycaemic events. RESULTS: In the general population, non-severe nocturnal hypoglycaemic events were associated with a 0.007 disutility compared with 0.004 for non-severe daytime episodes, equivalent to a significant 63% increase in negative impact. Severe daytime and nocturnal events were associated with a 0.057 and a 0.062 disutility, respectively, which were not significantly different. CONCLUSIONS: This study applies an established health economic methodology to derive disutilities associated with hypoglycaemia stratified by onset time and severity using a large multinational population. It reveals substantial individual and cumulative detrimental effects of hypoglycaemic events - particularly nocturnal - on HRQoL, reinforcing the clinical imperative of avoiding hypoglycaemia.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/23731777-
dc.rightsCopyright © 2013 Evans et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCanadaen
dc.subjectDiabetes Mellitus, Type 1en
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectFemaleen
dc.subjectGermanyen
dc.subjectGreat Britainen
dc.subjectHumansen
dc.subjectHypoglycemiaen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectQuality of Lifeen
dc.subjectQuestionnairesen
dc.subjectSwedenen
dc.subjectTime Factorsen
dc.subjectUnited Statesen
dc.titleHealth-related quality of life associated with daytime and nocturnal hypoglycaemic events: a time trade-off survey in five countriesen
dc.typeJournal Articleen
dc.identifier.doi10.1186/1477-7525-11-90-
dc.identifier.eissn1477-7525-
dc.identifier.pii1477-7525-11-90-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeComparative Study;Journal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Populationen
dc.dateaccepted2013-05-22-
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology



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