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|Title:||The endocannabinoid system and sex steroid hormone-dependent cancers|
Taylor, Anthony H.
Marczylo, Timothy H.
Willets, Jonathon M.
Konje, Justin C.
|Publisher:||Hindawi Publishing Corporation|
|Citation:||International Journal of Endocrinology, 2013, 259676|
|Abstract:||The "endocannabinoid system (ECS)" comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised transport system. Recent evidence suggests that both cannabinoid receptors are present in sex steroid hormone-dependent cancer tissues and potentially play an important role in those malignancies. Sex steroid hormones regulate the endocannabinoid system and the endocannabinoids prevent tumour development through putative protective mechanisms that prevent cell growth and migration, suggesting an important role for endocannabinoids in the regulation of sex hormone-dependent tumours and metastasis. Here, the role of the endocannabinoid system in sex steroid hormone-dependent cancers is described and the potential for novel therapies assessed.|
|Rights:||Copyright © 2013 Thangesweran Ayakannu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Appears in Collections:||Published Articles, College of Medicine, Biological Sciences and Psychology|
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