Please use this identifier to cite or link to this item:
Title: The endocannabinoid system and sex steroid hormone-dependent cancers
Authors: Ayakannu, Thangesweran
Taylor, Anthony H.
Marczylo, Timothy H.
Willets, Jonathon M.
Konje, Justin C.
First Published: 2013
Publisher: Hindawi Publishing Corporation
Citation: International Journal of Endocrinology, 2013, 259676
Abstract: The "endocannabinoid system (ECS)" comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised transport system. Recent evidence suggests that both cannabinoid receptors are present in sex steroid hormone-dependent cancer tissues and potentially play an important role in those malignancies. Sex steroid hormones regulate the endocannabinoid system and the endocannabinoids prevent tumour development through putative protective mechanisms that prevent cell growth and migration, suggesting an important role for endocannabinoids in the regulation of sex hormone-dependent tumours and metastasis. Here, the role of the endocannabinoid system in sex steroid hormone-dependent cancers is described and the potential for novel therapies assessed.
DOI Link: 10.1155/2013/259676
ISSN: 1687-8337
eISSN: 1687-8345
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 Thangesweran Ayakannu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description: PMCID: PMC3863507
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

Files in This Item:
File Description SizeFormat 
The endocannabinoid system and sex steroid hormone-dependent cancers..pdfPublished (publisher PDF)1.14 MBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.