Please use this identifier to cite or link to this item:
Title: The molecular approach to diagnosis in lung cancer
Authors: Moore, David A.
Le Quesne, John P. C.
First Published: 11-May-2015
Publisher: Mark Allen Healthcare
Citation: Br J Hosp Med (Lond), 2015, 76 (5), pp. C74-C76
Abstract: From Introduction: Lung cancer is the biggest cause of cancer death in the UK (CRUK, 2014). It is a biologically very diverse disease, and shows striking variation seen in histological appearances, which are reflect high levels of genomic changes with concomitant diversity of tumour cellular biology (reviewed in Shames and Wistuba, 2014). Despite this, until a decade ago, a simple classification into two categories, small cell or non-small cell, was the only one relevant to disease management. Small-cell carcinoma generally gave a good initial response to chemotherapy, whereas only non-small cell disease was amenable to surgical cure and there was no clinical reason for pathologists to attempt further classification of non-small cell carcinomas. This review will examine the subsequent developments in lung cancer diagnosis and look forward to how emerging technologies and improved understanding of tumour biology are likely to further transform the pathological diagnosis of this disease.
DOI Link: 10.12968/hmed.2015.76.5.C74
ISSN: 1750-8460
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Archived with reference to SHERPA/RoMEO.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

Files in This Item:
File Description SizeFormat 
final.pdfPost-review (final submitted)261.08 kBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.