Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32663
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dc.contributor.authorRandall, J. C.-
dc.contributor.authorWinkler, T. W.-
dc.contributor.authorKutalik, Z.-
dc.contributor.authorBerndt, S. I.-
dc.contributor.authorJackson, A. U.-
dc.contributor.authorMonda, K. L.-
dc.contributor.authorKilpeläinen, T. O.-
dc.contributor.authorEsko, T.-
dc.contributor.authorMägi, R.-
dc.contributor.authorLi, S.-
dc.contributor.authorWorkalemahu, T.-
dc.contributor.authorFeitosa, M. F.-
dc.contributor.authorCroteau-Chonka, D. C.-
dc.contributor.authorDay, F. R.-
dc.contributor.authorFall, T.-
dc.contributor.authorFerreira, T.-
dc.contributor.authorGustafsson, S.-
dc.contributor.authorLocke, A. E.-
dc.contributor.authorMathieson, I.-
dc.contributor.authorScherag, A.-
dc.contributor.authorVedantam, S.-
dc.contributor.authorWood, A. R.-
dc.contributor.authorLiang, L.-
dc.contributor.authorSteinthorsdottir, V.-
dc.contributor.authorThorleifsson, G.-
dc.contributor.authorDermitzakis, E. T.-
dc.contributor.authorDimas, A. S.-
dc.contributor.authorKarpe, F.-
dc.contributor.authorMin, J. L.-
dc.contributor.authorNicholson, G.-
dc.contributor.authorClegg, D. J.-
dc.contributor.authorPerson, T.-
dc.contributor.authorKrohn, J. P.-
dc.contributor.authorBauer, S.-
dc.contributor.authorBuechler, C.-
dc.contributor.authorEisinger, K.-
dc.contributor.authorDIAGRAM Consortium-
dc.contributor.authorBonnefond, A.-
dc.contributor.authorFroguel, P.-
dc.contributor.authorMAGIC Investigators-
dc.contributor.authorHottenga, J. J.-
dc.contributor.authorProkopenko, I.-
dc.contributor.authorWaite, L. L.-
dc.contributor.authorHarris, T. B.-
dc.contributor.authorSmith, A. V.-
dc.contributor.authorShuldiner, A. R.-
dc.contributor.authorMcArdle, W. L.-
dc.contributor.authorCaulfield, M. J.-
dc.contributor.authorMunroe, P. B.-
dc.contributor.authorGrönberg, H.-
dc.contributor.authorChen, Y. D.-
dc.contributor.authorLi, G.-
dc.contributor.authorBeckmann, J. S.-
dc.contributor.authorJohnson, T.-
dc.contributor.authorThorsteinsdottir, U.-
dc.contributor.authorTeder-Laving, M.-
dc.contributor.authorKhaw, K. T.-
dc.contributor.authorWareham, N. J.-
dc.contributor.authorZhao, J. H.-
dc.contributor.authorAmin, N.-
dc.contributor.authorOostra, B. A.-
dc.contributor.authorKraja, A. T.-
dc.contributor.authorProvince, M. A.-
dc.contributor.authorCupples, L. A.-
dc.contributor.authorHeard-Costa, N. L.-
dc.contributor.authorKaprio, J.-
dc.contributor.authorRipatti, S.-
dc.contributor.authorSurakka, I.-
dc.contributor.authorCollins, F. S.-
dc.contributor.authorSaramies, J.-
dc.contributor.authorTuomilehto, J.-
dc.contributor.authorJula, A.-
dc.contributor.authorSalomaa, V.-
dc.contributor.authorErdmann, J.-
dc.contributor.authorHengstenberg, C.-
dc.contributor.authorLoley, C.-
dc.contributor.authorSchunkert, H.-
dc.contributor.authorLamina, C.-
dc.contributor.authorWichmann, H. E.-
dc.contributor.authorAlbrecht, E.-
dc.contributor.authorGieger, C.-
dc.contributor.authorHicks, A. A.-
dc.contributor.authorJohansson, A.-
dc.contributor.authorPramstaller, P. P.-
dc.contributor.authorKathiresan, S.-
dc.contributor.authorSpeliotes, E. K.-
dc.contributor.authorPenninx, B .-
dc.contributor.authorHartikainen, A. L.-
dc.contributor.authorJarvelin, M. R.-
dc.contributor.authorGyllensten, U.-
dc.contributor.authorBoomsma, D. I.-
dc.contributor.authorCampbell, H.-
dc.contributor.authorWilson, J. F.-
dc.contributor.authorChanock, S. J.-
dc.contributor.authorFarrall, M.-
dc.contributor.authorGoel, A.-
dc.contributor.authorMedina-Gomez, C.-
dc.contributor.authorRivadeneira, F.-
dc.contributor.authorEstrada, K.-
dc.contributor.authorUitterlinden, A. G.-
dc.contributor.authorHofman, A.-
dc.contributor.authorZillikens, M. C.-
dc.contributor.authorden Heijer, M.-
dc.contributor.authorKiemeney, L. A.-
dc.contributor.authorMaschio, A.-
dc.contributor.authorHall, P.-
dc.contributor.authorTyrer, J.-
dc.contributor.authorTeumer, A.-
dc.contributor.authorVölzke, H.-
dc.contributor.authorKovacs, P.-
dc.contributor.authorTönjes, A.-
dc.contributor.authorMangino, M.-
dc.contributor.authorSpector, T. D.-
dc.contributor.authorHayward, C.-
dc.contributor.authorRudan, I.-
dc.contributor.authorHall, A. S.-
dc.contributor.authorSamani, N. J.-
dc.contributor.authorAttwood, A. P.-
dc.contributor.authorSambrook, J. G.-
dc.contributor.authorHung, J.-
dc.contributor.authorPalmer, L. J.-
dc.contributor.authorLokki, M. L.-
dc.contributor.authorSinisalo, J.-
dc.contributor.authorBoucher, G.-
dc.contributor.authorHuikuri, H.-
dc.contributor.authorLorentzon, M.-
dc.contributor.authorOhlsson, C.-
dc.contributor.authorEklund, N.-
dc.contributor.authorEriksson, J. G.-
dc.contributor.authorBarlassina, C.-
dc.contributor.authorRivolta, C.-
dc.contributor.authorNolte, I. M.-
dc.contributor.authorSnieder, H.-
dc.contributor.authorVan der Klauw, M. M.-
dc.contributor.authorVan Vliet-Ostaptchouk, J. V.-
dc.contributor.authorGejman, P. V.-
dc.contributor.authorShi, J.-
dc.contributor.authorJacobs, K. B.-
dc.contributor.authorWang, Z.-
dc.contributor.authorBakker, S. J.-
dc.contributor.authorMateo Leach, I.-
dc.contributor.authorNavis, G.-
dc.contributor.authorvan der Harst, P.-
dc.contributor.authorMartin, N. G.-
dc.contributor.authorMedland, S. E.-
dc.contributor.authorMontgomery, G. W.-
dc.contributor.authorYang, J.-
dc.contributor.authorChasman, D. I.-
dc.contributor.authorRidker, P. M.-
dc.contributor.authorRose, L. M.-
dc.contributor.authorLehtimäki, T.-
dc.contributor.authorRaitakari, O.-
dc.contributor.authorAbsher, D.-
dc.contributor.authorIribarren, C.-
dc.contributor.authorBasart, H.-
dc.contributor.authorHovingh, K. G.-
dc.contributor.authorHyppönen, E.-
dc.contributor.authorPower, C.-
dc.contributor.authorAnderson, D.-
dc.contributor.authorBeilby, J. P.-
dc.contributor.authorHui, J.-
dc.contributor.authorJolley, J.-
dc.contributor.authorSager, H.-
dc.contributor.authorBornstein, S. R.-
dc.contributor.authorSchwarz, P. E.-
dc.contributor.authorKristiansson, K.-
dc.contributor.authorPerola, M.-
dc.contributor.authorLindström, J.-
dc.contributor.authorSwift, A. J.-
dc.contributor.authorUusitupa, M.-
dc.contributor.authorAtalay, M.-
dc.contributor.authorLakka, T. A.-
dc.contributor.authorRauramaa, R.-
dc.contributor.authorBolton, J. L.-
dc.contributor.authorFowkes, G.-
dc.contributor.authorFraser, R. M.-
dc.contributor.authorPrice, J. F.-
dc.contributor.authorFischer, K.-
dc.contributor.authorKrjutå Kov, K.-
dc.contributor.authorMetspalu, A.-
dc.contributor.authorMihailov, E.-
dc.contributor.authorLangenberg, C.-
dc.contributor.authorLuan, J.-
dc.contributor.authorOng, K. K.-
dc.contributor.authorChines, P. S.-
dc.contributor.authorKeinanen-Kiukaanniemi, S. M.-
dc.contributor.authorSaaristo, T. E.-
dc.contributor.authorEdkins, S.-
dc.contributor.authorFranks, P. W.-
dc.contributor.authorHallmans, G.-
dc.contributor.authorShungin, D.-
dc.contributor.authorMorris, A. D.-
dc.contributor.authorPalmer, C. N.-
dc.contributor.authorErbel, R.-
dc.contributor.authorMoebus, S.-
dc.contributor.authorNöthen, M. M.-
dc.contributor.authorPechlivanis, S.-
dc.contributor.authorHveem, K.-
dc.contributor.authorNarisu, N.-
dc.contributor.authorHamsten, A.-
dc.contributor.authorHumphries, S. E.-
dc.contributor.authorStrawbridge, R. J.-
dc.contributor.authorTremoli, E.-
dc.contributor.authorGrallert, H.-
dc.contributor.authorThorand, B.-
dc.contributor.authorIllig, T.-
dc.contributor.authorKoenig, W.-
dc.contributor.authorMüller-Nurasyid, M.-
dc.contributor.authorPeters, A.-
dc.contributor.authorBoehm, B. O.-
dc.contributor.authorKleber, M. E.-
dc.contributor.authorMärz, W.-
dc.contributor.authorWinkelmann, B. R.-
dc.contributor.authorKuusisto, J.-
dc.contributor.authorLaakso, M.-
dc.contributor.authorArveiler, D.-
dc.contributor.authorCesana, G.-
dc.contributor.authorKuulasmaa, K.-
dc.contributor.authorVirtamo, J.-
dc.contributor.authorYarnell, J. W.-
dc.contributor.authorKuh, D.-
dc.contributor.authorWong, A.-
dc.contributor.authorLind, L.-
dc.contributor.authorde Faire, U.-
dc.contributor.authorGigante, B.-
dc.contributor.authorMagnusson, P. K.-
dc.contributor.authorPedersen, N. L.-
dc.contributor.authorDedoussis, G.-
dc.contributor.authorDimitriou, M.-
dc.contributor.authorKolovou, G.-
dc.contributor.authorKanoni, S.-
dc.contributor.authorStirrups, K.-
dc.contributor.authorBonnycastle, L. L.-
dc.contributor.authorNjølstad, I.-
dc.contributor.authorWilsgaard, T.-
dc.contributor.authorGanna, A.-
dc.contributor.authorRehnberg, E.-
dc.contributor.authorHingorani, A.-
dc.contributor.authorKivimaki, M.-
dc.contributor.authorKumari, M.-
dc.contributor.authorAssimes, T. L.-
dc.contributor.authorBarroso, I.-
dc.contributor.authorBoehnke, M.-
dc.contributor.authorBorecki, I. B.-
dc.contributor.authorDeloukas, P.-
dc.contributor.authorFox, C. S.-
dc.contributor.authorFrayling, T.-
dc.contributor.authorGroop, L. C.-
dc.contributor.authorHaritunians, T.-
dc.contributor.authorHunter, D.-
dc.contributor.authorIngelsson, E.-
dc.contributor.authorKaplan, R.-
dc.contributor.authorMohlke, K. L.-
dc.contributor.authorO'Connell, J. R.-
dc.contributor.authorSchlessinger, D.-
dc.contributor.authorStrachan, D. P.-
dc.contributor.authorStefansson, K.-
dc.contributor.authorvan Duijn, C. M.-
dc.contributor.authorAbecasis, G. R.-
dc.contributor.authorMcCarthy, M. I.-
dc.contributor.authorHirschhorn, J. N.-
dc.contributor.authorQi, L.-
dc.contributor.authorLoos, R. J.-
dc.contributor.authorLindgren, C. M.-
dc.contributor.authorNorth, K. E.-
dc.contributor.authorHeid, I. M.-
dc.date.accessioned2015-07-14T11:17:08Z-
dc.date.available2015-07-14T11:17:08Z-
dc.date.issued2013-06-06-
dc.identifier.citationPLoS Genetics, 2013, 9 (6), e1003500en
dc.identifier.issn1553-7390-
dc.identifier.urihttp://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003500en
dc.identifier.urihttp://hdl.handle.net/2381/32663-
dc.description.abstractGiven the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5×10(-8)), but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/23754948-
dc.rightsThis is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.en
dc.subjectAnthropometryen
dc.subjectBody Heighten
dc.subjectBody Mass Indexen
dc.subjectBody Weighten
dc.subjectBody Weights and Measuresen
dc.subjectFemaleen
dc.subjectGenetic Locien
dc.subjectGenome, Humanen
dc.subjectGenome-Wide Association Studyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectSex Characteristicsen
dc.subjectWaist Circumferenceen
dc.subjectWaist-Hip Ratioen
dc.titleSex-stratified genoSex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traitsen
dc.typeJournal Articleen
dc.identifier.doi10.1371/journal.pgen.1003500-
dc.identifier.eissn1553-7404-
dc.identifier.piiPGENETICS-D-12-01098-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Genome Scienceen
dc.dateaccepted2013-03-15-
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences



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