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Title: Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis
Authors: Proitsi, P.
Lupton, M. K.
Velayudhan, L.
Newhouse, S.
Fogh, I.
Tsolaki, M.
Daniilidou, M.
Pritchard, M.
Kloszewska, I.
Soininen, H.
Mecocci, P.
Vellas, B.
Alzheimer's Disease Neuroimaging Initiative
Williams, J.
GERAD1 Consortium
Stewart, R.
Sham, P.
Lovestone, S.
Powell, J. F.
First Published: 16-Sep-2014
Publisher: Public Library of Science
Citation: PLoS Medicine, 2014, 11 (9), e1001713
Abstract: Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory results have been reported. We have used a Mendelian randomization approach to dissect the causal nature of the association between circulating lipid levels and late onset AD (LOAD) and test the hypothesis that genetically raised lipid levels increase the risk of LOAD.
DOI Link: 10.1371/journal.pmed.1001713
ISSN: 1549-1277
eISSN: 1549-1676
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Proitsi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: PMCID: PMC4165594
Appears in Collections:Published Articles, Dept. of Health Sciences

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