Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32727
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dc.contributor.authorBodicoat, Danielle H.-
dc.contributor.authorGray, Laura J.-
dc.contributor.authorHenson, Joseph-
dc.contributor.authorWebb, David-
dc.contributor.authorGuru, A.-
dc.contributor.authorMisra, A.-
dc.contributor.authorGupta, R.-
dc.contributor.authorVikram, N.-
dc.contributor.authorSattar, N.-
dc.contributor.authorDavies, Melanie J.-
dc.contributor.authorKhunti, Kamlesh-
dc.date.accessioned2015-07-20T10:28:26Z-
dc.date.available2015-07-20T10:28:26Z-
dc.date.issued2014-03-05-
dc.identifier.citationPLoS One, 2014, 9 (3), e90813en
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090813en
dc.identifier.urihttp://hdl.handle.net/2381/32727-
dc.description.abstractAIMS: To derive cut-points for body mass index (BMI) and waist circumference (WC) for minority ethnic groups that are risk equivalent based on endogenous glucose levels to cut-points for white Europeans (BMI 30 kg/m[superscript: 2]; WC men 102 cm; WC women 88 cm). MATERIALS AND METHODS: Cross-sectional data from participants aged 40-75 years: 4,672 white and 1,348 migrant South Asian participants from ADDITION-Leicester (UK) and 985 indigenous South Asians from Jaipur Heart Watch/New Delhi studies (India). Cut-points were derived using fractional polynomial models with fasting and 2-hour glucose as outcomes, and ethnicity, objectively-measured BMI/WC, their interaction and age as covariates. RESULTS: Based on fasting glucose, obesity cut-points were 25 kg/m[superscript: 2] (95% Confidence Interval: 24, 26) for migrant South Asian, and 18 kg/m[superscript: 2] (16, 20) for indigenous South Asian populations. For men, WC cut-points were 90 cm (85, 95) for migrant South Asian, and 87 cm (82, 91) for indigenous South Asian populations. For women, WC cut-points were 77 cm (71, 82) for migrant South Asian, and 54 cm (20, 63) for indigenous South Asian populations. Cut-points based on 2-hour glucose were lower than these. CONCLUSIONS: These findings strengthen evidence that health interventions are required at a lower BMI and WC for South Asian individuals. Based on our data and the existing literature, we suggest an obesity threshold of 25 kg/m[superscript: 2] for South Asian individuals, and a very high WC threshold of 90 cm for South Asian men and 77 cm for South Asian women. Further work is required to determine whether lower cut-points are required for indigenous, than migrant, South Asians.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/24599391-
dc.rightsCopyright © 2014 Bodicoat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAsian Continental Ancestry Groupen
dc.subjectBlood Glucoseen
dc.subjectBody Mass Indexen
dc.subjectCross-Sectional Studiesen
dc.subjectEthnic Groupsen
dc.subjectEuropean Continental Ancestry Groupen
dc.subjectFemaleen
dc.subjectGreat Britainen
dc.subjectHumansen
dc.subjectIndiaen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectWaist Circumferenceen
dc.titleBody Mass Index and Waist Circumference Cut-Points in Multi-Ethnic Populations from the UK and India: The ADDITION-Leicester, Jaipur Heart Watch and New Delhi Cross-Sectional Studiesen
dc.typeJournal Articleen
dc.identifier.doi10.1371/journal.pone.0090813-
dc.identifier.eissn1932-6203-
dc.identifier.piiPONE-D-13-36006-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/No themeen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Populationen
dc.dateaccepted2014-02-04-
Appears in Collections:Published Articles, Dept. of Health Sciences



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