Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32751
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dc.contributor.authorChacón, M.-
dc.contributor.authorJara, J. L.-
dc.contributor.authorPanerai, Ronney B.-
dc.date.accessioned2015-07-20T12:42:21Z-
dc.date.available2015-07-20T12:42:21Z-
dc.date.issued2014-10-14-
dc.identifier.citationPLoS One, 2014, 9 (10), e108281en
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108281en
dc.identifier.urihttp://hdl.handle.net/2381/32751-
dc.description.abstractThe classic dynamic autoregulatory index (ARI), proposed by Aaslid and Tiecks, is one of the most widely used methods to assess the efficiency of dynamic cerebral autoregulation. Although this index is often used in clinical research and is also included in some commercial equipment, it exhibits considerable intra-subject variability, and has the tendency to produce false positive results in clinical applications. An alternative index of dynamic cerebral autoregulation is proposed, which overcomes most of the limitations of the classic method and also has the advantage of being model-free. This new index uses two parameters that are obtained directly from the response signal of the cerebral blood flow velocity to a transient decrease in arterial blood pressure provoked by the sudden release of bilateral thigh cuffs, and a third parameter measuring the difference in slope of this response and the change in arterial blood pressure achieved. With the values of these parameters, a corresponding classic autoregulatory index value could be calculated by using a linear regression model built from theoretical curves generated with the Aaslid-Tiecks model. In 16 healthy subjects who underwent repeated thigh-cuff manoeuvres, the model-free approach exhibited significantly lower intra-subject variability, as measured by the unbiased coefficient of variation, than the classic autoregulatory index (p = 0.032) and the Rate of Return (p<0.001), another measure of cerebral autoregulation used for this type of systemic pressure stimulus, from 39.23%±41.91% and 55.31%±31.27%, respectively, to 15.98%±7.75%.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/25313519-
dc.rightsCopyright © 2014 Chacón et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectAdulten
dc.subjectBlood Flow Velocityen
dc.subjectCardiovascular Diseasesen
dc.subjectCerebrovascular Circulationen
dc.subjectHomeostasisen
dc.subjectHumansen
dc.subjectMiddle Ageden
dc.subjectModels, Cardiovascularen
dc.subjectRegression Analysisen
dc.subjectUltrasonography, Doppler, Transcranialen
dc.titleA New Model-Free Index of Dynamic Cerebral Blood Flow Autoregulationen
dc.typeJournal Articleen
dc.identifier.doi10.1371/journal.pone.0108281-
dc.identifier.eissn1932-6203-
dc.identifier.piiPONE-D-13-39162-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Neuroscience & Behaviouren
dc.dateaccepted2014-08-28-
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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