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Title: Tracking genomic cancer evolution for precision medicine: the lung TRACERx study
Authors: Jamal-Hanjani, M.
Hackshaw, A.
Ngai, Y.
Shaw, Jacqueline
Dive, C.
Quezada, S.
Middleton, G.
de Bruin, E.
Le Quesne, John
Shafi, S.
Falzon, M.
Horswell, S.
Blackhall, F.
Khan, I.
Janes, S.
Nicolson, M.
Lawrence, D.
Forster, M.
Fennell, Dean
Lee, SM
Lester, J.
Kerr, K.
Muller, Salli
Iles, N.
Smith, S.
Murugaesu, N.
Mitter, R.
Salm, M.
Stuart, A.
Matthews, N.
Adams, H.
Ahmad, T.
Attanoos, R.
Bennett, Jonathan
Birkbak, N. J.
Booton, R.
Brady, G.
Buchan, K.
Capitano, A.
Chetty, M.
Cobbold, M.
Crosbie, P.
Davies, H.
Denison, A.
Djearman, M.
Goldman, J.
Haswell, T.
Joseph, L.
Kornaszewska, M.
Krebs, M.
Langman, G.
MacKenzie, M.
Millar, J.
Morgan, Bruno
Naidu, B.
Nonaka, D.
Peggs, K.
Pritchard, Catrin
Remmen, H.
Rowan, A.
Shah, R.
Smith, E.
Summers, Y.
Taylor, M.
Veeriah, S.
Waller, David
Wilcox, B.
Wilcox, M.
Woolhouse, I.
McGranahan, N.
Swanton, C.
First Published: 8-Jul-2014
Publisher: Public Library of Science
Citation: PLoS Biol, 2014, 12 (7), e1001906
Abstract: The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.
DOI Link: 10.1371/journal.pbio.1001906
eISSN: 1545-7885
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Jamal-Hanjani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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