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Title: The multifaceted effects of omega-3 polyunsaturated Fatty acids on the hallmarks of cancer
Authors: Stephenson, James Andrew
Al-Taan, Omer
Arshad, Ali
Morgan, Bruno
Metcalfe, Matthew S.
Dennison, Ashley
First Published: 2013
Publisher: Hindawi Publishing Corporation
Citation: Journal of Lipids, 2013, 2013, 261247
Abstract: Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-3 polyunsaturated fatty acid in cancer protection in relation to self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion, and how these will hopefully translate from bench to bedside.
DOI Link: 10.1155/2013/261247
ISSN: 2090-3030
eISSN: 2090-3049
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2013 J. A. Stephenson et al. This is an open access article distributed under the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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