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|Title:||The multifaceted effects of omega-3 polyunsaturated Fatty acids on the hallmarks of cancer|
|Authors:||Stephenson, James Andrew|
Metcalfe, Matthew S.
|Publisher:||Hindawi Publishing Corporation|
|Citation:||Journal of Lipids, 2013, 2013, 261247|
|Abstract:||Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-3 polyunsaturated fatty acid in cancer protection in relation to self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion, and how these will hopefully translate from bench to bedside.|
|Rights:||Copyright © 2013 J. A. Stephenson et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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