Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/32869
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dc.contributor.authorCoppo, R.-
dc.contributor.authorTroyanov, S.-
dc.contributor.authorBellur, S.-
dc.contributor.authorCattran, D.-
dc.contributor.authorCook, H. T.-
dc.contributor.authorFeehally, John-
dc.contributor.authorRoberts, I. S.-
dc.contributor.authorMorando, L.-
dc.contributor.authorCamilla, R.-
dc.contributor.authorTesar, V.-
dc.contributor.authorLunberg, S.-
dc.contributor.authorGesualdo, L.-
dc.contributor.authorEmma, F.-
dc.contributor.authorRollino, C.-
dc.contributor.authorAmore, A.-
dc.contributor.authorPraga, M.-
dc.contributor.authorFeriozzi, S.-
dc.contributor.authorSegoloni, G.-
dc.contributor.authorPani, A.-
dc.contributor.authorCancarini, G.-
dc.contributor.authorDurlik, M.-
dc.contributor.authorMoggia, E.-
dc.contributor.authorMazzucco, G.-
dc.contributor.authorGiannakakis, C.-
dc.contributor.authorHonsova, E.-
dc.contributor.authorSundelin, B. B.-
dc.contributor.authorDi Palma, A. M.-
dc.contributor.authorFerrario, F.-
dc.contributor.authorGutierrez, E.-
dc.contributor.authorAsunis, A. M.-
dc.contributor.authorBarratt, Jonathan-
dc.contributor.authorTardanico, R.-
dc.contributor.authorPerkowska-Ptasinska, A.-
dc.contributor.authorVALIGA study of the ERA-EDTA Immunonephrology Working Group-
dc.date.accessioned2015-08-04T09:41:18Z-
dc.date.available2015-08-04T09:41:18Z-
dc.date.issued2014-04-02-
dc.identifier.citationKidney International, 2014, 86 (4), pp. 828-836en
dc.identifier.urihttp://www.nature.com/ki/journal/v86/n4/full/ki201463a.htmlen
dc.identifier.urihttp://hdl.handle.net/2381/32869-
dc.description.abstractThe Oxford Classification of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as independent predictors of outcome. Whether it applies to individuals excluded from the original study and how therapy influences the predictive value of pathology remain uncertain. The VALIGA study examined 1147 patients from 13 European countries that encompassed the whole spectrum of IgAN. Over a median follow-up of 4.7 years, 86% received renin-angiotensin system blockade and 42% glucocorticoid/immunosuppressive drugs. M, S, and T lesions independently predicted the loss of estimated glomerular filtration rate (eGFR) and a lower renal survival. Their value was also assessed in patients not represented in the Oxford cohort. In individuals with eGFR less than 30 ml/min per 1.73 m(2), the M and T lesions independently predicted a poor survival. In those with proteinuria under 0.5 g/day, both M and E lesions were associated with a rise in proteinuria to 1 or 2 g/day or more. The addition of M, S, and T lesions to clinical variables significantly enhanced the ability to predict progression only in those who did not receive immunosuppression (net reclassification index 11.5%). The VALIGA study provides a validation of the Oxford classification in a large European cohort of IgAN patients across the whole spectrum of the disease. The independent predictive value of pathology MEST score is reduced by glucocorticoid/immunosuppressive therapy.en
dc.language.isoenen
dc.publisherNature Publishing Group for International Society of Nephrologyen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/24694989-
dc.rightsCopyright © 2014 International Society of Nephrology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/ ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAtrophyen
dc.subjectChilden
dc.subjectDisease Progressionen
dc.subjectEuropeen
dc.subjectFemaleen
dc.subjectFibrosisen
dc.subjectFollow-Up Studiesen
dc.subjectGlomerular Filtration Rateen
dc.subjectGlomerular Mesangiumen
dc.subjectGlomerulonephritis, IGAen
dc.subjectGlomerulosclerosis, Focal Segmentalen
dc.subjectHumansen
dc.subjectImmunosuppressive Agentsen
dc.subjectKidneyen
dc.subjectKidney Failure, Chronicen
dc.subjectKidney Tubulesen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeovascularization, Pathologicen
dc.subjectPredictive Value of Testsen
dc.subjectProteinuriaen
dc.subjectRenin-Angiotensin Systemen
dc.subjectRetrospective Studiesen
dc.subjectYoung Adulten
dc.titleValidation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments.en
dc.typeJournal Articleen
dc.identifier.doi10.1038/ki.2014.63-
dc.identifier.eissn1523-1755-
dc.identifier.piiki201463-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article;Multicenter Study;Research Support, Non-U.S. Gov't;Validation Studies-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
dc.dateaccepted2014-01-02-
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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