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Title: Abnormal IgD and IgA1 O-glycosylation in hyperimmunoglobulinaemia D and periodic fever syndrome
Authors: de Wolff, J. F.
Dickinson, Stephen J.
Smith, Alice C.
Molyneux, Karen
Feehally, John
Simon, A.
Barratt, Jonathan
First Published: 20-Jun-2009
Publisher: Springer Verlag
Citation: Clinical and Experimental Medicine, 2009, 9 (4), pp. 291-296
Abstract: In order to determine the glycosylation pattern for IgD, and to examine whether there are changes in the pattern of IgD and IgA1 O-glycosylation in patients with hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS) during acute febrile attacks and during periods of quiescence, serum was obtained from 20 patients with HIDS and 20 control subjects. In the HIDS group, serum was obtained either during an acute febrile episode (n = 9) or during a period of quiescence (n = 11). The O-glycosylation profiles of native and desialylated IgA1 and IgD were measured in an ELISA-type system using the lectins Helix aspersa and peanut agglutinin, which bind to alternative forms of O-glycan moieties. IgD is more heavily O-galactosylated and less O-sialylated than IgA1 in healthy subjects. HIDS is associated with more extensive O-galactosylation of IgD and a reduction in O-sialylation of both IgD and IgA1. These changes are present both during acute febrile attacks and periods of quiescence. The T cell IgD receptor is a lectin with binding affinity for the O-glycans of both IgD and IgA1. The observed changes in IgD and IgA1 O-glycosylation are likely to have a significant effect on IgD/IgA1-T cell IgD receptor interactions including basal immunoglobulin synthesis, and possibly myeloid IgD receptor-mediated cytokine release.
DOI Link: 10.1007/s10238-009-0056-y
ISSN: 1591-8890
eISSN: 1591-9528
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © The Authors, 2009. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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