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Title: The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis
Authors: Jelleyman, Charlotte
Yates, Thomas
Gray, Laura J.
O'Donovan, Gary
King, James A.
Khunti, Kamlesh
Davies, Melanie J.
First Published: 20-Oct-2015
Publisher: Wiley for International Association for the Study of Obesity
Citation: Obesity Reviews, 2015, 16: 942–961
Abstract: The aim of this meta-analysis was to quantify the effects of high-intensity interval training (HIIT) on markers of glucose regulation and insulin resistance compared to control conditions (CON) or continuous training (CT). Databases were searched for HIIT interventions based on the inclusion criteria: training ≥2 weeks, adult participants, and outcome measurements that included insulin resistance, fasting glucose, HbA1c or fasting insulin. Dual interventions and participants with type 1 diabetes were excluded. Fifty studies were included. There was a reduction in insulin resistance following HIIT compared to both CON & CT, (HIIT vs. CON: standardised mean difference (SMD)=-0.49, confidence intervals (CI) -0.87 to -0.12, p=0.009; CT: SMD=-0.35, -0.68 to -0.02, p=0.036). Compared to CON, HbA1c decreased by 0.19% (-0.36 to -0.03, p=0.021) and body weight decreased by 1.3kg (-1.9 to -0.7, p<0.001). There were no statistically significant differences between groups in other outcomes overall. However, participants with or at risk of Type 2 diabetes experienced reductions in fasting glucose (-0.92mmol.L-1, -1.22 to -0.62, p<0.001) compared to CON. HIIT appears effective at improving metabolic health, particularly in those at risk of or with Type 2 diabetes. Larger randomised controlled trials of longer duration than those included in this meta-analysis are required to confirm these results.
DOI Link: 10.1111/obr.12317
ISSN: 1467-7881
eISSN: 1467-789X
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: This is the peer reviewed version of the following article: Obesity Reviews, 16: 942–961, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Appears in Collections:Published Articles, Dept. of Health Sciences

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