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|Title:||Neurochemical measurements in the zebrafish brain|
|Authors:||Norton, William H. J.|
McCutcheon, James E.
Young, Andrew M. J.
|Citation:||Frontiers in Behavioral Neuroscience, Sept 2015, 9:246. doi: 10.3389/fnbeh.2015.00246|
|Abstract:||The zebrafish is an ideal model organism for behavioural genetics and neuroscience. The high conservation of genes and neurotransmitter pathways between zebrafish and other vertebrates permits the translation of research between species. Zebrafish behaviour can be studied at both larval and adult stages and recent research has begun to establish zebrafish models for human disease. Fast scan cyclic voltammetry (FSCV) is an electrochemical technique that permits the detection of neurotransmitter release and reuptake. In this study we have used in vitro FSCV to measure the release of analytes in the adult zebrafish telencephalon. We compare different stimulation methods and present a characterisation of neurochemical changes in the wild-type zebrafish brain. This study represents the first FSCV recordings in zebrafish, thus paving the way for neurochemical analysis of the fish brain.|
|Rights:||Copyright © 2015 Jones, McCutcheon, Young and Norton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.|
|Appears in Collections:||Published Articles, Dept. of Biology|
Files in This Item:
|fnbeh-09-00246.pdf||Published (publisher PDF)||1.47 MB||Adobe PDF||View/Open|
|148886_Norton_Manuscript.PDF||Post-review (final submitted)||1.16 MB||Adobe PDF||View/Open|
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