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Title: Rapid Encoding of New Memories by Individual Neurons in the Human Brain
Authors: Ison, Matias J.
Quian Quiroga, Rodrigo
Fried, Itzhak
First Published: 1-Jul-2015
Publisher: Elsevier (Cell Press)
Citation: Neuron, 2015, 87 (1), pp. 220-230
Abstract: The creation of memories about real-life episodes requires rapid neuronal changes that may appear after a single occurrence of an event. How is such demand met by neurons in the medial temporal lobe (MTL), which plays a fundamental role in episodic memory formation? We recorded the activity of MTL neurons in neurosurgical patients while they learned new associations. Pairs of unrelated pictures, one of a person and another of a place, were used to construct a meaningful association modeling the episodic memory of meeting a person in a particular place. We found that a large proportion of responsive MTL neurons expanded their selectivity to encode these specific associations within a few trials: cells initially responsive to one picture started firing to the associated one but not to others. Our results provide a plausible neural substrate for the inception of associations, which are crucial for the formation of episodic memories.
DOI Link: 10.1016/j.neuron.2015.06.016
ISSN: 0896-6273
eISSN: 1097-4199
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2015. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Engineering

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